Yes you can. Use any caliber handgun ammo from .22s Throo .45s. and any caliber rifle ammo from .223, Throo 50 Cal. .308, .30-06 and 50 Cal. hits leave just a pinhole through THROOM™ targets. Optimum bullet velocity typically ranges from 750 fps (feet per second) to 1,250 fps. With handgun ammo you can shoot THROOM™ targets close up on a softwood target stand within 5 to 10-feet or out at 15 to 50-yards. Rifle ammo runs much faster than handgun ammo, so for rifle ammo, it’s best to set THROOM™ targets at 50 to 150 yards or more in order to get good target reaction to your hits. Some soft tip hunting rounds will make a small entrance hole in the front and a larger exit hole out the back.